About - Dr. Alexander Krannich



  • Independent Biostatistician

BioStats, Nauen

Januar 2017 – present

  • Head of Analytics & Data Science

Telehealth Competence Center GmbH (TCC), Hamburg

September 2021 – present

  • Guest Scientist, Experimental and Clinical Research Center (ECRC)

Charité - Universitätsmedizin Berlin, Germany

September 2021 – present

  • Head of Clinical Trial Office with eight Teams, including the Biostatistics Team

Berlin Institute of Health and Charité - Universitätsmedizin Berlin, Germany

Juli 2019 – August 2021

  • Statistician and Manager Health Technology Assessment & Outcomes Research

(Oncology & internal medicine)

Pfizer Deutschland GmbH, Berlin, Germany

April 2018 – Juni 2019

  • Senior Biostatistician and Functional Lead

Astellas Pharma (urology), Boehringer Ingelheim, UCB (neurology), Roche (oncology), Merck (immunology), InDex Pharmaceuticals (gastroenterology)

PAREXEL International GmbH, Berlin, Germany

October 2016 – March 2018

  • Biostatistician

Coordination Center for Clinical Trials, Berlin Institute of Health and Charité - Universitätsmedizin Berlin, Germany

July 2012 – September 2016

  • Assistant Biostatistics

Coordination Center for Clinical Trials, Charité - Universitätsmedizin Berlin, Germany

September 2009 – June 2012

  • Vocational training and employment, community service, studies

1996 – 2009



  • Dr. rer. medic. (summa cum laude), Charité - Universitätsmedizin Berlin, Berlin, Germany
  • M.Sc. Clinical Trial Management with focus on Statistics, Beuth University of Applied Sciences Berlin with courses at Harvard Medical School and Humboldt Universität zu Berlin, Berlin, Germany and Boston, USA
  • B.Sc. Statistics, Magdeburg University of Applied Sciences, Magdeburg/Germany


English: fluent, German: native



  • Statistical Editor, Journal of Cachexia, Sarcopenia and Muscle, Berlin, Germany, 2016 – Present
  • Statistical Editor, JCSM Clinical Reports, Berlin, Germany, 2016 – Present
  • Statistical Editor, ESC Heart Failure, Berlin, Germany, 2016 – Present
  • Guest Scientist, Max Delbrück Center for Molecular Medicine, Berlin, Germany, 2016 – 2018
  • Appointed Member Section Biostatistics, Charité Institutional Review Board, 2012 - 2016
  • Lecturer Biostatistics and Epidemiology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 2011 – 2015


  • International Biometric Society (IBS)
  • World Association of Medical Editors (WAME)
  • Statisticians in the Pharmaceutical Industry (PSI)



  • Statistical advice and functional lead role within cross functional teams
  • Lead of production and quality control of randomizations, analysis plans, statistical reports, statistical sections of integrated clinical reports and other process supporting documents
  • QC of derived datasets, tables, figures and data listings produced by programmers
  • Role as an independent statistician for DMC/DSMB
  • Providing and discussing study design as well as sample size scenarios,
  • Support of budget and proposal development, attending and preparing bid defense meetings
  • Training and education of students and professionals


  • Descriptive statistics and simple hypothesis tests
  • General linear models (e.g. ANOVA, ANCOVA)
  • Generalized linear models (e.g. logistic or Poisson regression)
  • Analysis of clustered, longitudinal and repeated measures data (e.g. linear mixed models or generalized estimation equations)
  • Survival analysis (e.g. Cox regression or competing risk regression)
  • Diagnostic tests including model validation

Special methodical

  • Analysis of cross over designs, time series analysis, principal components analysis, meta- analysis, non-inferiority and equivalence analysis, adaptive designs, special non-parametric analysis (e.g. Brunner analysis), principal component analysis, estimands, artificial neural nets

Software skills

  • Statistical programming: R, SAS
  • Sample size calculation: nQuery, ADDPLAN